Quantification of tertiary structural conservation despite primary sequence drift in the globin fold
نویسندگان
چکیده
منابع مشابه
In Silico Analysis of Primary Sequence and Tertiary Structure of Lepidium Draba Peroxidase
Peroxidase enzymes are vastly applicable in industry and diagnosiss. Recently, we introduced a new kind of peroxidase gene from Lepidium draba (LDP). According to protein multiple sequence alignment results, LDP had 93% similarity and 88.96% identity with horseradish peroxidase C1A (HRP C1A). In the current study we employed in silico tools to determine, to which group of peroxidase enzymes LDP...
متن کاملEffective use of sequence correlation and conservation in fold recognition.
Protein families are a rich source of information; sequence conservation and sequence correlation are two of the main properties that can be derived from the analysis of multiple sequence alignments. Sequence conservation is related to the direct evolutionary pressure to retain the chemical characteristics of some positions in order to maintain a given function. Sequence correlation is attribut...
متن کاملStructural drift: a possible path to protein fold change
SUMMARY Along with their mutating sequences, protein structures change in time. Analyzing a formate dehydrogenase domain that is evolutionarily related to ferredoxin, but simultaneously contains all the structural elements of a beta-Grasp fold, we illustrate here a mechanism termed as structural drift, by which changes to a protein fold can occur. CONTACT [email protected].
متن کاملStructural drift corresponding to the critical excitations
While the existing structures, even recently constructed ones are subjected to the critical earthquakes, the catastrophic devastations are expected to occur. Therefore, at least for several important structures such as power plants, infrastructure, and buildings, there is a need to consider the critical excitation analysis. One of the important criteria in the seismic design of the structures u...
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ژورنال
عنوان ژورنال: Protein Science
سال: 1994
ISSN: 0961-8368,1469-896X
DOI: 10.1002/pro.5560031009